11^th International Conference on Stroke and Neurological Disorders August 22-23, 2024 Berlin, Germany

Prof., Ph.D., M.D., Head of Department and Clinic of Rehabilitation, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, Poland. Specializations in pediatrics and rehabilitation. Member of scientific bodies: Bioethics Commission and Program Council of the Faculty of Medicine, University of Warmia and Mazury in Olsztyn, Senate Ethics Commission, Experts Team at the Ministry of Health for developing a Posture problems prevention program for children and adolescents in the educational environment, National Examination Committee in the field of Medical Rehabilitation and Medical Experts Team of National Accreditation Commission. Polish Annals of Medicine Editor-in-Chief, Journal of Elementology (ISI Master Journal List Impact Factor – 0,643) Editor/Scientific Committee member, The Journal of Spine Surgery Scientific Council member, Polish Journal of Rehabilitation Research Consultants Team member, National Report for Disabled Scientific Consultant. Director of 4 Research Projects founded by Scientific Research Committee and Ministry of Science and Higher Education, 3 European Union’s Projects member, author of 312 scientific articles and 3 academic textbooks. Awarded the Silver Cross of Merit for achievements in research, teaching and social activities, posted in Who is Who in Poland, Verlag fur Personenezyklopedien, Schweiz and Who's Who in the World, 21st Edition, NJ, USA. Chairman for 8 terms of Warmia and Mazury Department and General Board of the Polish Rehabilitation Society member, as well as member in other numerous scientific organizations: International Society of Physical and Rehabilitation Medicine, Baltic & North Sea Forum on Physical and Rehabilitation Medicine – Board and Scientific Committee, Society on Scoliosis Orthopedic and Rehabilitation Treatment, Society on Scoliosis Orthopedic and Rehabilitation Treatment – founder of the Polish Group, Section of Spondyloorthopedics of the Polish Society of Orthopedics and Traumathology and Polish Society of Spinal Surgery.

Pediatrics and Rehabilitation

He has published 620 articles, including reviews and chapters in textbooks on Neonatology. Of these more than 160 are recorded in Medline. The main topics are hypoxia, hypoxiareoxygenation injury, the effect of free radicals in the neonatal period, and mechanisms of brain injury. He is involved with the organization of several European Conferences, and in the coordination of numerous pan-European clinical trials. He is the Coordinator of the European scientific network EURAIBI (acronym for EURope Against Infant Brain Injury). His research interests are in the mechanisms of cell damage in the neonatal brain, with special reference to hypoxia, the role of oxidant radicals in neonatal diseases and in babies with birth asphyxia. His research team is funded by several agencies including the Italian Ministry of University and Scientific Researchcofinance scheme for research projects of high national interest.

Pediatric Neurology, Neonatal Neurology, Neonatology, Perinatology

Gentile Salvatore is a MD, Phy.D. Psychiatrist, Neurologist and working as an Adjunct professor of Perinatal Psychiatry- Medical School “Federico II” – Department of Neurosciences - Division of Psychiatry - Naples – Italy.

Psychiatry , Neurology

Dr. Talbert is and Honorary Senior Lecturer in Bio-Medical Engineering at Institute of Reproductive and Developmental Biology Imperial College School of Medicine Queen Charlotte’s Hospital

Pediatric Neurology, Neurology

Ivan G. Milanov is a highly accomplished neurologist and healthcare leader from Bulgaria. He earned his MD in 1981, specializing in movement disorders, multiple sclerosis, headache, pain, and clinical electromyography. He's held prominent positions in academia and medical societies, including serving as the President of multiple Bulgarian neurological organizations. Dr. Milanov has also made significant contributions as an editor for various medical journals.

Rsearch Interest: movement disorders, multiple sclerosis, headache, pain, clinical electromyography

Graduated in Biological Sciences (D.Sc.) and in Medicine and Surgery (M.D.) - Associate Professor of Pharmacology at University of Pavia -Teaching Pharmacology for students in Biological Sciences and in Chemistry - Visiting: (1) Department of Neurology and (2) Cerebral Metabolism Research Laboratory, University of Lund, Sweden; (3) Department of Psychobiology, University of California ICI, U.S.A.; (4) Max Plank Institute for Neurochemistry, University of Gottingen, Germany; (5) San Diego Alzheimer’s Disease Research Center, University of California, San Diego, U.S.A.. Research activities: biochemical studies (Functional Proteomics and Metabolomics) on Physiopathology and Pharmacology of the Central Nervous System in experimental conditions of hypoxia, ischaemia, hyperammoniaemia, ipoglycaemia on the cerebral energy metabolism and actions of drugs on the brain energy state; molecular mechanisms of ageing and drugs' interference; the study of Parkinson’s disease and drugs' actions in Dementia; clinical studies on Molecular Medicine and Human Genetics on patients affected by neurological diseases (Dementia) or Alzheimer’s disease. Scientific research activity: 349 total papers: no. 129 on peer international reviews (IF about 350, only ISI publications); no. 66 Congress Proceedings and Acts; no. 154 communications in International Meetings, participating to no. 219 scientific Congress; officially invited to no. 214 Congress since 1993; from 2010 no. 56 as speaker; 9 Member of Organizing Committee or Session Chair/Co-Chair. International appointments as: (A) International ad hoc Reviewer for: - Research Founding Grants (Neuroscience) of The Wellcome Trust Foundation, London, United Kingdom (since 1994) - British Medical Council (asked 2014) inserted as - Reviewer’s Database for Founding of United Kingdom SBS, North Star House, Swinodon, U.K. - Listed as International Expert for the evaluation of Research Grant Programs of the European Commission Research Directorate General, Life Sciences: Health Research, European Union, Brussels. - Reviewer’s Database of Journal of Neuroscience - Reviewer’s Database of European Journal of Neurology And Committee Member of Italian Ministry for Scientific Research Grants (MIUR). (B) Member of the International Experts Panel of the Medical Science Monitor (since 2003), Albertson, New York, U.S.A. (C) Participant to ex Internship Program for U.S.A. students of New York Academy of Science, New York, U.S.A. Accredited Researcher for grants at National Institute of Health (NIH - U.S.A.). (D) Medical Credits at San Diego Alzheimer’s Disease Research Center Conference of University of California, San Diego, U.S.A. (E) Member of the Editorial Boards of: - Member of the Science Advisory Board – Arlington, U.S.A.. - Member of the Editorial Board of “Neurological Disorders & Therapy” – U.S.A. - VIP Member of EB of Neural Regeneration Research, Supervisor Ministry of Health - China (until 2013). - Member of EB of Journal of Neurological Disorders - Member of EB of “Aging and Neurodegeneration” – Anhui Medical University, China - Academic Editor of International Neuropsychiatric Disease Journal. - Member of EB of Journal of Depression and Anxiety – Los Angeles, California, U.S.A.. - Member of EB of International Journal of Emergency Mental Health and Human Resilience – Foster City, California, U.S.A.. - Member of EB of International Journal of Neurology Research – Sheung Wan, Hong Kong (China) - Member of EB of Journal of Neurology and Neuroscience – Wilmington City, Delaware, U.S.A.. (N) ad hoc Reviewer for over of 25 Journals: (in 1989) for Circulation Research; reviewer (from 1989) for Mechanisms of Ageing and Development; reviewer (in 2003) for Molecular Brain Research; reviewer (in 2004) of the Cochrane Dementia and Cognitive Improvement Group, Department of Clinical Gerontology, Oxford, U.K.; reviewer (since 2004) for Experimental Gerontology; reviewer (in 2004) for the “Bioastronautics Critical Path Roadmap Document”, Bioastronautics Research Division of NASA, U.S.A.; reviewer (since 2004) of The Journal of Clinical Pharmacology; reviewer (from 2011) of Complementary Medicine and Drug Discovery; reviewer (in 2011) for Drugs Today, Prous Thomson Reuters; reviewer (in 2011) for Neuropharmacology, Vascular Pharmacology, Journal of Neurological Disorder; reviewer (in 2012) for Vascular BMC Neurology; reviewer (in 2013) for Journal Neuroscience Research, Free Radical Research, Pharmacological Reports, PLOS ONE, Journal of Cytology & Histology, Neurological Research; reviewer (from 2014) for Neurochemical Research, Neural Regeneration Research, Journal Neurological Disorders (4 times), Molecular Neurobiology, Journal Proteome Research (3 times), Neuroscience Letters (3 times), Recent Patents on CNS Drug Discovery (Bentham Science Eds), Neuroscience Research, British Medical Journal, Metabolic Brain Disease.

Research Interests: Biochemical studies (Functional Proteomics and Metabolomics) on Physiopathology and Pharmacology of the Central Nervous System in experimental conditions of hypoxia, ischaemia, hyperammoniaemia, ipoglycaemia on the cerebral energy metabolism and actions of drugs on the brain energy state; molecular mechanisms of ageing and drugs' interference; the study of Parkinson’s disease and drugs' actions in Dementia; clinical studies on Molecular Medicine and Human Genetics on patients affected by neurological diseases (Dementia) or Alzheimer’s disease.

Born in Jammu-Tawi, India. After receiving Bachelor’s degree in Pharmaceutical Technology from the Birla Institute of Technology, Pilani, India, Rameshwar K. Sharma in 1960 entered the University of Connecticut for graduate work in Medicinal Chemistry and received his Ph.D. in 1963. Subsequently, after several Post-doctoral positions, including at the Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, he joined the University of Tennessee Medical Center at Memphis in 1970 where he rose to the rank of Full Tenured Professor of Biochemistry and Physiology. During this period through NIH Special Fellowship he spent two-years Sabbatical as a Visiting Professor at the McArdle Laboratory University of Wisconsin, Madison, in Dr. Henry Pitot’s lab, and subsequently additional two-years Sabbatical at the NIH, Bethesda in Dr. Michael Cashel’s lab. After Full Professorship at the Case Western University and Founder and Head of the Unit of Regulatory Biology at the Cleveland Clinic Foundation, Cleveland Ohio, he joined the University of Medicine and Dentistry at New Jersey as the Professor and Head of The Unit of Regulatory and Molecular Biology. Since July 2006 he is at the Salus University as a Distinguished Professor of Biochemistry and Molecular Biology. In a period spanning four decades, his research team has dedicated itself to the advancement of the field of membrane guanylate cyclase in the vertebrate systems. A few of its core findings that have impacted this and the field of cellular signal transduction follow. (1) With the discovery of the first membrane guanylate cyclase, ANF-RGC that was also the hormone receptor of ANF, the membrane guanylate cyclase surface receptor family was established. (2) It had a unique signal transduction mechanism. Instead of GTP in G-Protein signaling, it was regulated by ATP through its ARM module (ARM). The complete dissection of the module, followed through the concept-based analysis, localized a WTAPELL motif that controlled the entire signal transduction process, it was, then, predicted that this motif is the one that controls the ANF-RGC-dependent blood pressure in vasculature. This has now been proven true through the construction of the mouse genetic model. The mice lacking this motif are hypertensive. (3) The discovery and molecular characterization of the photoreceptor ROS-GC is a land mark event in the phototransduction field. It filled in the gap on the identity of the source of cyclic GMP that serves as a second messenger of the LIGHT signal; and made it possible to explain the principles of phototransduction in molecular and physiological terms. It also impacted the core membrane guanylate cyclase field by branching it into two: a transducer of both the hormone receptor and the intracellularly-generated Ca2+ signals. (4) ROS-GC field took additional direction when it was demonstrated that, besides phototransduction, it is biochemically linked with the transduction mechanisms of the inner segments of the retina, olfactory cilia and the olfactory bulb neurons. (5) The demonstration that ROS-GC is a Ca2+-bimodal switch, generated a new revolutionary concept where theoretically ROS-GC could be modulated through two different modes of Ca2+ signaling: via Ca2+-sensor GCAPS and S100B, the latter stimulating it and the mode found exclusively in cones and absent in rods. (6) Recently, an additional model of the photoreceptor ROS-GC1 has been disclosed. ROS-GC1 is responsive to the bicarbonate signal; it is not the pH effect, rather it binds to a specific motif of the ROS-GC and transduces the signal in generation of cyclic GMP. Preliminary findings suggest that this novel transduction system is present in a small number of mouse cones, and, importantly, is absent in the rods. This opens up a new area of sensory transduction mechanism, where it is meant to communicate with the external atmospheric carbon dioxide. The carbon dioxide is sensed through carbonic anhydrase, whose subtype has been detected in some cones, it converts CO2 to the bicarbonate, which, then, becomes the second messenger of CO2 and a signaling agent of ROS-GC1. Threaded through this past history and step-by-step gain in the field, This investigator feels fortunate that his group has made these important contributions in generating the field of membrane guanylate cyclase, establishing that cyclic GMP is an ubiquitous intracellular second messenger in prokaryotes and eukaryotes and that it plays a critical role in the control of physiological processes of cardiac vasculature, smooth muscle relaxation, blood volume, cellular growth, sensory transduction, neural plasticity, learning and memory. It is also gratifying to know that during this course he has been able to train and guide more than 35 doctoral and post-doctoral students, author 184 peer-reviewed research articles, including the editorship of three books, Special Editorship of two journals of Molecular and Cellular Biochemistry and the e-book editor of the Frontiers Molecular Neuroscience Research Topic, all focused on the field of membrane guanylate cyclases. At present I am on the editorial board of four international journals: Associate editor of the Frontiers in Molecular Neuroscience, Journal of Molecular and Cellular Biochemistry, Journal of Signal Transduction, Journal of Membrane Science & Technology. I am also the founding father and the President of the Guanylate Cyclase Innovative Biotechnology (www.gcibiotechnology.com).

Research Interest: Membrane guanylate cyclase in the vertebrate systems

He joined the neuropsychiatry residency at Ain shams university Cairo, Egypt from 2001 till 2003, finished his MD in neurology and got his doctorate by 2008. He have been assigned as lecturer of neurology and his main concern was in the field of NEUROVASCULAR INTERVENTIONAL RADIOLOGY. He finished his fellowship in interventional neurology at ZURICH University, Switzerland as F.I.N.R. by 2013. Now he is an Assistant clinical professor of neurology, GMU University and GMC hospital, Ajman, united Arab of emirates (UAE) SINCE 2010. He have publications in many journals as OPEN JOURNAL OF MEDICAL IMAGING (OJMI), The Egyptian Journal of Radiology and Nuclear Medicine, the European Journal of Neurology, Neurology of India. He is an editor in chief at NEUROLOGICAL SCIENCE JOURNAL

Stroke, Epilepsy Managment

Academic graduation - Doctor of medicine graduated from Monastir

Neurology

Clinical & basic science trained neurologist with neuromuscular/rare/orphan disease fellowships and therapeutics development expertise in Neurology, Cardiology and Rare Disease applications.

Neuromuscular

He is the Vice Chair of Neurology Department. He is associate professor of Neurology & Radiology Department at Texas Tech University Health Science Center. With him comes around 15 years of experience in the field of Neurology.

Neurology & Radiology

Jerzy Leszek is a full time professor of psychiatry at the Medical University in Wroclaw , Poland ,vice –director of the Psychiatry Department and head of Alzheimer’s Disease Lab. He is author and co-author more than 210 papers (especially from old age psychiatry), some chapters to the books published in reputed Polish and international journals and serving as an editorial board member of several journals .He is Scientific Editor and co-author of first Polish academic handbook on Alzheimer’s disease and seven another academic handbooks from psychogeriatry , member a lot of scientific associations eg founder and president of Lower Silesian Association of Alzheimer’s Families, first of its kind in Poland and Former Member of Board of Directions of International Psychogeriatric Association and President of Polish Psychogeriatric Association.

Neurodegeneration processes/Alzheimer’s disease Therapy of dementia disorders in the light of new technologies :nanotechnology, proteomics, metabolomics, genomic medicine, personalized therapy Molecular base of neurodegenerative disorders Rehabilitation and physical activity of dementia disorders