Marie Lhedie L. Garrovillas MD
World Citi Medical Center, Quezon City, Philippines
Title: Correlation of Elevated Troponin I as Predictor of Poor Outcome in Young Patients With Acute Ischemic Stroke Without Acute Coronary Syndrome in a Tertiary General Hospital: A Two-Year Retrospective Study
Biography
Biography: Marie Lhedie L. Garrovillas MD
Abstract
Objective: Heart disease and stroke are the leading causes of death globally and they may occur concurrently. Although troponin I is the ideal marker for acute coronary syndrome, its elevation can also be seen in other diseases, including stroke. The objective of this study is to be able to correlate elevated troponin I as predictor of poor outcome in patients with acute cerebrovascular stroke without acute coronary syndrome. Methods: This is a two-year retrospective cohort study among young patients diagnosed with cerebrovascular accident in a tertiary general hospital from September 2016 to September 2018. Study population is composed of young adult (19 – 45 years old) who had acute cerebrovascular infarct without acute coronary syndrome. Troponin I determined upon admission was reviewed and patients were stratified into troponin I less than 0.21mg/dL and troponin more than 0.21 mg/dL. Results: 134 were included in the study, 129 patients had troponin I less than 0.21 mg/dL and 5 patients had troponin I more than 0.21 mg/dL. The data showed that there is no statistical difference in the distribution of sex and age group of stroke patients, with or without elevated troponin I level, with p-value of 0.08. However, troponin I level is statistically associated with longer hospital stay, ICU admission and stroke severity with pvalue of 0.0001. The mean hospital stay among those with elevated troponin I was 29.2 days (+11.07) as compared to less than 0.21 troponin, with mean hospital admission of 4.79 days (+0.34). Troponin I level has positive moderate correlation with increased stroke severity, length of hospital stay, and ICU admission with r = 0.24 (p-value = 0.0052), r = 0.32 (p-value = 0.0002) and r = 0.47 (p-value = 0.0001), respectively. Conclusion: Elevated troponin I can categorize patient with acute cerebrovascular infarct without acute coronary syndrome as high-risk. Elevated troponin I has positive moderate