Oladepo Mutiu Lolade
Adekunle Ajasin University, Ngeria
Title: EFFECT OF SAPONIN FROM SOLANUM ANGUIVI ON HEART FUNCTION OF ALLOXAN INDUCED DIABETIC RATS.
Biography
Biography: Oladepo Mutiu Lolade
Abstract
Solanum anguivi is a semi-domestic indigenous vegetable very valuable in many African countries with potential to becoming a cultivated market vegetable in Nigeria.Uptake of Solanum anguivi cause hypoglycemic effect, hypertension e.t.c. The effect of Saponin from solanum anguivi on heart function of alloxan induced diabetic rat was investigated in this Study. Twenty four (24) rats of average weight 120g were randomly divided into six (6) groups A-F. Group A (control) rats were given 2.0ml of distilled water , Group B (Diabetic control), Group C to F were diabetic rats which were administered 20mg/kg , 40mg/kg and 80mg/kg Saponin from solanum anguivi respectively for 14 days. The results showed that there was a significant reduction in plasma glucose in the diabetic rat to almost the level in the Control. The result also shows that, there was a significant reduction in Aspartate Aminotransferase AST and Alanine aminotransferase ALT activities in serum and heart compare with the control (p<0.05). This study show that solanum anguivi fruit has anti-diabetic effect on alloxan induced diabetic rat.