Blood Brain Barrier Integrity

Blood brain barrier integrity focuses on the selective barrier that protects neural tissue from toxins, pathogens, and fluctuations in blood composition. The barrier is formed by tightly connected endothelial cells supported by astrocytes and pericytes, creating a highly controlled interface between the bloodstream and the brain. Its transport systems regulate the movement of nutrients, ions, and metabolic products while restricting harmful substances. When the barrier becomes compromised, inflammatory molecules, proteins, and immune cells can enter the brain and disrupt cellular balance. Barrier dysfunction influences neuronal excitability, oxidative stress, and synaptic stability. This structural and functional decline plays a major role in stroke pathology, neuroinflammation, and chronic neurological disorders. Restoring barrier stability is a key focus in many therapeutic approaches.

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