Stroke Summit 2026 | March 30-31, 2026

Neuroinflammation and Immune Response

Neuroinflammation and immune response describe how the central nervous system reacts to harmful stimuli such as injury, infection, toxins, or degenerative processes. Microglial cells act as primary immune regulators within the brain and become activated when they detect cellular damage or abnormal protein accumulation. Astrocytes contribute to inflammatory signaling by releasing chemical mediators that influence neural survival and tissue repair. Prolonged activation of inflammatory pathways can alter synaptic communication, affect neurotransmitter balance, and disrupt normal neuronal function. Cytokines, chemokines, and reactive oxygen species interact with neural structures and influence the progression of neurological disorders. The immune response also affects the stability of the blood brain barrier, allowing additional molecules to enter or exit the brain tissue during stress. This complex interaction between neural and immune systems shapes the long-term outcome of many brain conditions and contributes to both protective and harmful changes within neural networks.

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