Stroke Summit 2026 | March 30-31, 2026

Molecular Mechanisms of Neurodegeneration

Molecular mechanisms of neurodegeneration examine how changes inside nerve cells lead to gradual loss of their structure and function. Abnormal accumulation of misfolded proteins, oxidative stress, mitochondrial dysfunction, and impaired cellular clearance processes contribute to neuronal damage. Altered neurotransmitter production, disrupted synaptic communication, and abnormalities in energy regulation also influence the progression of degenerative changes. Inflammatory responses within the central nervous system affect the survival and stability of neurons, while genetic mutations can interfere with normal protein folding and transport. Molecular pathways involving protein aggregation, cellular stress responses, and impaired autophagy play a vital role in the decline of neuronal health. These mechanisms collectively influence memory decline, reduced cognitive abilities, and impaired motor functions. Understanding these molecular changes supports improved exploration of the processes that affect long-term neuronal stability.

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