Stroke Summit 2026 | March 30-31, 2026

Synaptic Transmission and Plasticity

Synaptic transmission and plasticity explain how nerve cells communicate and adapt to new information. Electrical signals travel along neurons and convert into chemical messengers that cross the synapse to activate receptors on neighboring cells. This communication controls memory formation, learning processes, sensory responses, and motor coordination. Synaptic plasticity allows connections between neurons to strengthen or weaken based on repetitive activity, environmental input, and internal chemical signals. Long-term potentiation and long-term depression modify the efficiency of synaptic communication and influence the formation of stable neural networks. Molecular changes within the synapse, including receptor trafficking, protein synthesis, and neurotransmitter regulation, play a central role in adaptation. These processes support the development of complex behaviors, cognitive flexibility, and stable neural circuitry.

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